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Home :: Immune Disorders

Chronic Mucocutaneous Candidiasi - Causes and Treatment


Acquired Immunodeficiency Syndrome
Allergic Rhinitis
Ankylosing Spondylitis
Blood Transfusion Reaction
Chronic Mucocutaneous Candidiasis
Common Variable Immunodeficiency
Digeorge Syndrome
Fibromyalgia Syndrome
Goodpastures Syndrome
Juvenile Rheumatoid Arthritis
Lupus Erythematosus
Polymyalgia Rheumatica
Polymyositis Dermatomyositis
Reiters Syndrome
Sjogrens Syndrome
Systemic Sclerosis
Urticaria Angioedem

Chronic mucocutaneous candidiasis is a rare condition occurring in childhood in which candida infection is persistent and widespread. Chronic mucocutaneous candidiasis is a heterogeneous disorder of the immune system. Chronic mucocutaneous candidiasis may be characterized by persistent candida infections of the mucous membranes, scalp, skin and nails. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait. Candida is a fungus of the yeast category. It may be associated with genetic predisposition with autosomal dominant inheritance (i.e. an abnormal gene from one parent) or autosomal recessive inheritance (an abnormal gene is inherited from each parent) or Endocrine conditions e.g. hypoparathyroidism, hypothyroidism, hypoadrenalism, diabetes mellitus and Immune defects. Chronic mucocutaneous candidiasis develops in adult life.

This is often as a result of a thymoma (tumour of the thymus gland) and is associated with internal diseases such as myasthenia gravis, myositis, aplastic anaemia, neutropaenia and hypogammaglobulinaemia. Chronic mucocutaneous candidiasis occur in childhood, there are a number of cases that first appear in adulthood, sometimes as late as 50 years of age. These chronic mucocutaneous candidiasis infections seldom produce systemic symptoms, but in late stages may be associated with recurrent respiratory tract infections. Symptoms may also be included hoarseness, dysphagia, and hemoptysis. There was poor correlation between oral lesions and laryngeal involvement. Most patients with chronic mucocutaneous candidiasis are treated with chronic that are specific for fungal infections.

Causes of Chronic Mucocutaneous Candidiasis

Common causes of Chronic Mucocutaneous Candidiasis

  • Fungus.
  • Immune dysregulation

Symptoms of Chronic Mucocutaneous Candidiasis

Common Symptoms of Chronic Mucocutaneous Candidiasis

  • Hoarseness.
  • Dysphagia.
  • Hemoptysis.
  • Blisters.
  • Infection of the cornea and eyelids.Endocrine disorders.
  • Diabetes.
  • Hemolytic anemia.
  • Autoimmune hair loss (alopecia).
  • Loss of skin pigment (vitiligo).
  • Endocrine disorders.
  • Autoimmune hair loss (alopecia).

Treatment of Chronic Mucocutaneous Candidiasis

Common Treatment of Chronic Mucocutaneous Candidiasis

  • Treatment depends on antifungal agents orally for repeated or prolonged courses often in higher doses than is normally necessary for candida infections(Fluconazole ,Itraconazole and Ketoconazole.
  • Infections may be treated with an antifungal drug- nystatin ( mycostatin, nilstat ) or clotrimazole ( lotrimi, mycelex )-applied to the skin. The primary contributing factor is the use of oral antibiotics.