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Home :: Immune Disorders

Blood Transfusion Reaction - Causes and Treatment


Acquired Immunodeficiency Syndrome
Allergic Rhinitis
Ankylosing Spondylitis
Blood Transfusion Reaction
Chronic Mucocutaneous Candidiasis
Common Variable Immunodeficiency
Digeorge Syndrome
Fibromyalgia Syndrome
Goodpastures Syndrome
Juvenile Rheumatoid Arthritis
Lupus Erythematosus
Polymyalgia Rheumatica
Polymyositis Dermatomyositis
Reiters Syndrome
Sjogrens Syndrome
Systemic Sclerosis
Urticaria Angioedem

Transfusion reaction is a complication of blood transfusion where there is an immune response against the transfused blood cells or other components of the transfusion. Chills and fever; backache or other aches and pains; hives and itching. In more serious situations, Blood cell destruction (hemolysis), causing shortness of breath, severe headache, chest or back pain and Blood in the urine The immune response normally protects the body from potentially harmful substances. Blood or from the use of incompletely matched Blood in an emergency. These substances trigger multiple responses, including production of antibodies (immunoglobulins, molecules that attach to a specific antigen and aid in its destruction), and sensitized lymphocytes that recognize a particular antigen and destroy it.

Blood plasma contains antibodies against the opposite antigen. Blood is classified according to the presence of these antigens, resulting in blood types A, B, AB,and O. People with Rhesus factors in their blood are classified as "Rh positive," while persons without the factors are classified as "Rh negative." Rh negative persons form antibodies against the Rh factor if they are exposed to Rh positive blood. Blood banks and hospitals train staff and have safety procedures in place to prevent transfusion reaction. Immune system attacks the donated blood cells, causing them to burst. Cause serious symptoms, including kidney failure and shock. Antigens also occur on other blood components, including white blood cells, platelets, and plasma proteins.

Causes of Blood Transfusion Reaction

Common causes of Blood Transfusion Reaction

  • Immunoglobulins.
  • Molecules.

Symptoms of Blood Transfusion Reaction

Common Symptoms of Blood Transfusion Reaction

  • Chills and fever.
  • Backache or other aches and pains
  • Hives and itching.
  • Shortness of breath
  • Headache.
  • Chest or back pain.
  • Blood in the urine.

Treatment of Blood Transfusion Reaction

Common Treatment of Blood Transfusion Reaction

  • Intravenous fluids and various medications may be used to treat/prevent kidney failure and shock.
  • Typing of donated blood into ABO and Rh groups has reduced the risk of transfusion reaction.
  • Blood is usually crossmatched to further confirm that the blood is compatible.
  • Antihistamines such as diphenhydramine may reduce itching and rash. Acetaminophen may be recommended to reduce fever and discomfort.