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Home :: Immune Disorders

Ankylosing Spondylitis - Causes and Treatment


Acquired Immunodeficiency Syndrome
Allergic Rhinitis
Ankylosing Spondylitis
Blood Transfusion Reaction
Chronic Mucocutaneous Candidiasis
Common Variable Immunodeficiency
Digeorge Syndrome
Fibromyalgia Syndrome
Goodpastures Syndrome
Juvenile Rheumatoid Arthritis
Lupus Erythematosus
Polymyalgia Rheumatica
Polymyositis Dermatomyositis
Reiters Syndrome
Sjogrens Syndrome
Systemic Sclerosis
Urticaria Angioedem

Ankylosing spondylitis is a form of chronic inflammation of the spine and the sacroiliac joints. Provide support to joints can lead to pain and tenderness in the ribs, shoulder blades, hips, thighs, shins, heels and along the bony points of the spine. Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. Ankylosing spondylitis is an autoimmune disease. As a reaction to the inflammation, a small amount of bone erosion occurs. After the inflammation has subsided, new bone is created as part of the healing process. It is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. Ankylosing spondylitis is an autoimmune disease. This means your immune system, which normally protects your body from infection, attacks your body's own tissues. Chronic tissue inflammation resulting from the continued activation of the body's own immune system in the absence of active infection is the hallmark of an inflammatory autoimmune disease.

Chronic spinal inflammation (spondylitis) can lead to a complete cementing together (fusion) of the vertebrae, a process referred to as ankylosis. Ankylosing spondylitis is a heredity back condition that cripples tens of thousands of people in the UK. Spondylarthropathies share a common genetic marker, called HLA-B27, in most affected individuals. In some cases, the disease occurs in these predisposed people after exposure to bowel or urinary tract infections. AS is a member of the family of diseases that attack the spine called spondylarthropathies. In addition to AS, these diseases include Reiter's syndrome, some cases of psoriatic arthritis and the arthitis of inflammatory bowel disease. Advanced spondylitis can lead to deposits of protein material called amyloid into the kidneys and result in kidney failure. Progressive kidney disease can lead to chronic fatigue and nausea and can require removal of accumulated blood poisons by a filtering machine.

Causes of Ankylosing Spondylitis

Common causes of Ankylosing Spondylitis

  • Gene(HLA-B27).
  • Genetic factors

Symptoms of Ankylosing Spondylitis

Common Symptoms of Ankylosing Spondylitis

  • Chronic stooping.
  • Stiff, inflexible spine.
  • Fatigue.
  • Loss of appetite.
  • Weight loss.
  • Eye inflammation.
  • Bowel inflammation. pain.
  • Redness.Blurred vision.
  • Sensitivity to bright light.
  • Fever.
  • Weight loss.
  • Eye inflammation.

Treatment of Ankylosing Spondylitis

Common Treatment of Ankylosing Spondylitis

  • Indomethacin is most effective,while sulfasalazine may benefit those with more severe involvement. Peripheral joint arthritis may respond to methotrexate.  
  • Rehabilitation therapies are essential. Proper sleep and walking positions, coupled with abdominal and back exercises, help maintain posture. Exercises help maintain joint flexibility. Breathing exercises enhance lung capacity, and swimming provides aerobic exercise.
  • Nonsteroidal anti-inflammatory medications (NSAIDs) such as aspirin are used to reduce inflammation and pain associated with the condition. They allow patients to exercise, which improves posture and breathing.
  • NSAIDs such as naproxen (Aleve, Naprosyn) and indomethacin (Indocin) are the medications doctors most commonly use to treat ankylosing spondylitis.
  • Corticosteroids. These medications, such as prednisone, may suppress inflammation and slow joint damage in severe cases of ankylosing spondylitis.
  • Aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) are commonly used to decrease pain and stiffness of the spine and other joints. Commonly used NSAIDs include indomethacin (Indocin), tolmetin (Tolectin), sulindac (Clinoril), naproxen (Naprosyn), and diclofenac (Voltaren).